Advanced Naturopathy Institute

Mauro Simonetti

The Clinical Evidence on Saffron and Mood Support

Saffron, the world’s most expensive spice, is starting to challenge what many people consider the “gold standard” for treating depression. Clinical studies have found that saffron performs comparably to common SSRIs like Prozac (fluoxetine) and Zoloft (sertraline) in managing depressive symptoms. In head-to-head trials, its effects were statistically similar, suggesting that for some people, this

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It’s Not Too Much Acid — It’s Not Enough (And It’s Disrupting Your Digestion)

Let’s put an end to the idea that stomach acid is the enemy, because for many people, that belief is doing more harm than good. Here’s the reality: without enough stomach acid, your body cannot properly break down and absorb nutrients, no matter how clean your diet is. You could be eating all the right

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Why Younger Adults Are Showing Signs of Joint Degeneration Earlier Than Previous Generations

Joint degeneration has traditionally been associated with aging, often appearing later in life. However, a growing body of research suggests that signs of cartilage damage and joint deterioration are appearing earlier than before, with many cases now being diagnosed in adults under 40. Healthcare professionals are increasingly observing early-onset joint issues, including chronic knee pain, hip degeneration,

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New Study Suggests Infection May Contribute to Heart Attacks, Beyond Cholesterol Alone

A groundbreaking study from Tampere University and the University of Oxford, published in the Journal of the American Heart Association (2025), is adding a new layer to our understanding of heart attack risk. For decades, cardiovascular disease has been primarily linked to cholesterol buildup, smoking, diabetes, high blood pressure, and lifestyle factors. While these remain well-established

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Why Sleeping in a Cool Room (18–20 °C) Improves Sleep Quality and Can Support Fat Loss

Sleep is one of the most powerful drivers of energy, recovery, mood, and metabolic health, yet it’s often underestimated. One of the simplest ways to improve it starting tonight is lowering your bedroom temperature. Research consistently shows that keeping your sleep environment between 18–20°C (64–68°F) helps your body fall asleep faster, stay asleep longer, and reach deeper

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Magnesium and Colorectal Cancer: What New Research Is Teaching Us

Magnesium is often marketed as a sleep supplement, but that label barely scratches the surface. This essential mineral is involved in over 300 metabolic processes in the body, including nerve function, blood sugar regulation, muscle contraction, vitamin D activation, and DNA repair. Increasingly, research shows that magnesium may also play an important role in cancer prevention, particularly colorectal

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Why Poor Sleep Sabotages Fat Loss (and Costs You Muscle)

If fat loss feels harder than it should, despite solid nutrition and training, sleep may be the missing piece. Research consistently shows that sleep deprivation disrupts key hormones that regulate appetite and body composition. Studies published in Annals of Internal Medicine demonstrate that reduced sleep increases ghrelin (hunger) while lowering leptin(satiety), making it easier to overeat and harder to feel

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Early Signs of Nutrient Deficiencies Your Labs May Miss

Most people wait for blood work to confirm that something is wrong. While lab testing is still the best way to understand what’s happening internally, the body often shows early signs of imbalance long before standard labs flag an issue. This is especially true when access to comprehensive testing is limited, as prevention and early

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Not Drinking Enough Water May Be Quietly Raising Your Stress Hormone

A new study shows that inadequate hydration doesn’t just affect energy or focus, it may amplify your body’s cortisol response to stress. I felt compelled to share this research because, in daily clinical practice, I’m consistently struck by how many people simply don’t drink enough water. Whether due to busy schedules, lack of thirst cues, or

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